Does a Heavy Workload Wear a Running Back Down? The Data Says No
The received wisdom is that a back who carries 25 times is compromised the following week. It is repeated constantly, it sounds like common sense, and the data points the other way. The effect is real and it runs in the opposite direction from the narrative.

What the numbers show
Backs coming off 25 or more carries averaged 76.8 rushing yards the following week and cleared a 59.5-yard threshold 58.3 percent of the time. Backs coming off lighter workloads cleared that same line 43.4 percent of the time.
That is a fifteen point gap in the wrong direction for the fatigue theory. A heavy previous week is associated with a better following week, not a worse one.
Why the intuition fails
The explanation is that carries are not primarily a measure of accumulated wear. They are a measure of what the coaching staff thinks of the player.
A back does not get 25 carries because he is available. He gets them because the staff trusts him, because the game script allowed it, and because he is the primary option in that offense. All three of those things persist into the following week far more reliably than fatigue accumulates across seven days with a full training and recovery apparatus.
So the high carry total is functioning as a proxy for role security, and role security is one of the most predictive things about a skill player. The fatigue signal is real but small, and it is swamped by the information the workload carries about the player's standing.
Where the effect breaks
The mechanism is also the limit. If the heavy workload is a signal about role, then anything that changes the role destroys the signal immediately.
A committee forming, a returning starter, a trade, a new coordinator, or a game script that turns pass-heavy all cancel it. The finding is not that carries are healthy. It is that carries in week one predict carries in week two, and carries predict yards.
Which means the number to actually watch is not last week's total. It is whether the reason for last week's total still holds.
The injury question, separately
None of this addresses long-term injury risk, and it should not be read as doing so. Whether a sustained heavy workload shortens a career is a different question on a different timescale, studied with different methods, and the week-to-week data has nothing to say about it.
The narrow claim is about next Sunday. Reading a box score where a back carried 18 times for 124 yards and three scores, the reasonable expectation for the following week is more of the same rather than less, unless something about the depth chart changed in between.